Adapt your resume to each job you apply for. Study the job description to determine why you are a great fit. Then, add your skills, experience and measurable achievements that are relevant to that position. Hiring managers who look through many resumes should be able to read yours and quickly know you have the skills for the position.
To simplify this step, have templates of your resume and cover letter ready to customize. Keep key sections such as your education and contact information the same, but personalize your abilities or past job duties to fit the job you are applying for.